Showing posts with label Psychology. Show all posts
Showing posts with label Psychology. Show all posts

Thursday, March 10, 2011

10 March 2011 - Anxious Meeces

It's no secret that I love mice.  I loooove mice.  Mice are amazing, useful, and interesting creatures.  It's always nice to see research done with them because it almost always directly applies itself to understanding them better, and not just whatever was being researched.  I am always game for learning more about mice.

So anyways - scientists found that while mice are normally very hesitant about wandering out into open spaces where they could be nabbed by a predator, this fear can actually be manipulated.  They targeted specific connections in the amygdalae of the brain (or between them, I believe), which when increased in activity caused the mice to become bolder and venture out.  When dampened, however, the mice became more anxious and stuck more frequently to the walls.  Basically, controlling this portion of the brain's activity allowed researchers to adjust the amount of anxiety the mice experienced.

Tye_Deisseroth_Supplementary Movie from Deisseroth Lab on Vimeo.


The implication of course is that anxiety in people can one day be similarly treated.  We're still quite a long way from that, but it's an interesting observation that will definitely lend itself to the study of anxiety, which in people is currently extremely difficult to treat!



-Miss Mouse



References and Links:
Mouse Braaaaaiiinns:
http://www.sciencenews.org/view/generic/id/70833/title/Anxiety_switch_makes_mice_shy_no_more

Monday, October 4, 2010

4 October 2010 - OCD, Breath-taking Treatments, and Terminal Cancer

Sunday's post is a day late, thanks to a severe case of the homeworks.  Actually, Tuesday's might not come at all due to the same extensive case, which will be culminating in four simultaneous tests.  :(  I'll be twittering my butt off now, though, since I have *gasp* my computer back!!

Today, I have a hefty dose of Vitamin Soft-Sciences.  And I'm going to spew it all over your computer screens.

Enough of that.

First up today is a study utilizing electrodes to treat otherwise unresponsive OCD, or obsessive compulsive disorder.  The study, published in the October Archives of General Psychiatry, implanted electrodes in the nucleus accumbens portion of the brain (which plays a role in rewards) in 16 patients whose OCD was unaffected by other treatments.  Then the study took place in three parts.  First, active stimulation (whatever that implies) was given over an eight month period to all participants, during which they were assessed for symptoms every two weeks using a 40 point scale.  Then comes the double-blind portion, in which for one month the patients were randomly assigned treatment or having the electrodes turned off for two weeks at a time.  Much assessing took place.  Finally, a year of stimulation again with 3-month assessments.  So...did it work?  Kinda!  Nine patients responded appreciably and decreases in symptoms were pretty evident (check out the link at bottom for details).  Side effects were forgetfulness and...uh...what's the term for...er...oh, right, word-finding problems.

While we have brains on the brain, there are also new and exciting findings concerning the breath-holding symptoms of Rett Syndrome, an autism spectrum disorder affecting 1 in 10,000 girls.  Breathing problems is just one of the symptoms, and can be lethal (not to mention terrifying).  Researchers found that in a mouse model with Rett Syndrome, the portion of the brain that controls breathing was actually low on a transmitter, aminobutyric acid.  So, by supplementing the aminobutyric acid and also stimulating a certain type of receptor, they successfully stopped the mouse's breathing problems, all using drugs already approved by the FDA.  Hopefully this approach will be made available quickly to help those who need it!

Last for today, because I've got quite a bit of studying to get to, new information has been found regarding terminal cancers and how to stop them in their latest stages.  Before, there didn't seem to be much you could do once the cancer had "spread."  Now, however, research is starting to show how those cancers spread and ways to target that method - specifically, something called platelet endothelial cell adhesion 1...or PECAM-1.  By creating an antibody, the anti-PECAM-1 antibody, a new approach becomes available for combatting several types of terminal cancers.  Details are in the link at the bottom of this post, but beware, it's a little full of itself.  :p

See you later!
-Miss Mouse

References and Links:
Shockingly OCD
http://www.newswise.com/articles/view/569171/
Okay, you can breathe now
http://www.physorg.com/news205425548.html
It's not over til it's over (Cancer, I mean)
http://www.newswise.com/articles/view/568884/

Sunday, April 11, 2010

11 April 2010 - Stressed Mice, Tuned In Medicine, Drug Resistance, and Viruses Creating Energy

Hi!  Hope everyone had a great weekend.  :)

I don't know if you noticed or not, but I added this nifty little Twitter feature to the right hand side of the page, just under "Labels."  This is for those of you who don't want to wait for each post to see new headlines!  I'll be tweeting links to various articles I find here and there, or retweeting as the case may be.  Just a nifty little idea.

First off, experiments in mice have found that the brains of those mice with only one copy of a gene that produces "brain-derived neurotrophic factor," or BDNF, are more affected by stress.  Apparently, stress in these mice causes the hippocampus area of the brain to shrink and the dendrites to withdraw, whereas mice with the normal two copies of the gene, and therefore a normal amount of BDNF, show no physical change in that area of the brain.  Researchers are now searching to find ways to control the amount of BDNF protein so they can determine when in development supplementation would be most effective.  Very interesting!

I know I heard about hallucinogenic testing going on here and there in the recent past, but I just found another article about it.  Scientists are gathering in California this week for a pretty big conference on the topic, particularly for use with OCD, end of life anxiety, depression, PTSD, and other psychological disorders.  I cannot say this doesn't make me pretty happy.  Check out the article link at the bottom of the post to read about various tests and reactions to psilocybin in groovy experiments.  :)

Everyone's biggest fear when it comes to antibiotics is that a superbug will become resistant to everything and we'll have nothing left to beat infections with, right?  Or is that just mine?  In any case, researchers have taken a close look at vancomycin, the "last resort" antibiotic, and actually determined the mechanism by which bacteria develop resistance to it.  It had been debated whether bacteria were tipped off to the antibiotic by noticing it directly, or noticing what it was doing to their cell walls.  It turns out the former is the case, the knowledge of which may help to develop sneakier antibiotics that could still go unnoticed.  Considering the growing number of people who are affected by resistant infections, this is pretty great progress!

Last for the weekend - researchers have devised a more direct method of splitting water molecules for use in solar powered energy...things.  Mimicking the photosynthesis process of plants, a group of scientists have utilized a harmless virus in a gel (to hold conformation) to do the splitting so that hydrogen can be stored for use at any time, rather than only when the sun is shining.  Original in its particular method, the system is still in its creation phase and needs to become more cost effective, efficient, and complete before going into effect.  An end date isn't set, but it's a valuable concept and it's nice to see that it works!



Check out the Twitter feed on the right hand side of the page to see the articles I didn't include today, but were still pretty neat.

Thanks for reading, and I'll see you Tuesday!
-Miss mouse



References and Links:
Stressed Out Mice
Psychedelic Medicine
Resistance!
Virus Energy

Thursday, April 8, 2010

8 April 2010 - Omnomnomium, Things That Don't Suffocate, Volcanoes, Animal-Census, Autism

Hey!

As promised, I've got some pretty interesting news today!  :)

First, you've probably already heard about element 117, and its recent, albeit brief, appearance in a Russian cyclotron.  Researchers fired calcium ions for 150 days at a target made of berkelium, finally producing SIX atoms of 117.  They existed for less than a second before decaying.  Now...what to call it?  Some amazing suggestions (from #namefornewelement on Twitter) include:
     - Yomommium
     - Nonsensium
     - Omnomnomium
     - Newishium
     - Holycrapium
     - Internetium
     - Surprisium
     - Pandemonium
     - Fatassium
     - DeLoreum
     - Noobium
     - Steve
     - Wowthatsheavyum
     - MasterChiefium
     - Unobtainium
     - Oneseventeenium
     - Wootonium
     - Porkchopsium

That's...amazing.  :)

Next, the first multicellular organisms able to survive completely without oxygen have been found in the sediment of the Mediterranean.  These three species of Loricifera are smaller than a millimeter and, oddly enough, have no mitochondria.  In pretty much every other animal cell, mitochondria are responsible for converting nutrients to energy.  These critters, however, use structures called hydrogenosomes to convert their food to energy without ever needing to use oxygen.  Since their rather extreme environment resembles ancient Earth before widespread oxygen, it's possible these little guys might be a peek into the past.

Also, the Venus Express orbiter has found new infrared evidence that suggests Venus maaay in fact have active volcanoes.  Of course by active, they mean within the past 250,000 years for most of them.  Since Venus sports fewer scars by asteroids than expected, it had been theorized before that either a massive volcanic event covered most of the surface at once a long time ago, or ongoing volcanoes have filled in various craters here and there over time.  This finding suggests the recent, active volcanoes option, which has interesting implications for the evolution of Earth, which is similar in many ways to Venus.

Back on Earth, a group of ecologists are planning to collect information on 160,000 species of life all over the planet to form a "barometer of life."  They selected the species involved in order to best represent all ecosystems, and the plan is to update it every five years with new information from hundreds of cooperating experts and scientists.  It's basically a census, but for animals, plants, and other.  The project is hoping to provide better and more complete information to aid in gauging the "health" of the planet, determining risks to biodiversity and the environment by companies and human activities, drawing attention to the environment and its inhabitants, and directing spending.  The project itself will cost an estimated 60 million USD, and will run an annual cost of around $5 million after that.

Last today, a few articles recently came out detailing advancements in Autism research.  For those of you who know me well, you already know how big of a deal Autism spectrum disorders are for me, so this is really exciting!  First, a program at Canisius College involving 5 weeks of "summer camp" programs for children affected by high functioning autism, Asperger's, and PDD-NOS paired with parent education has shown marked improvement in the emotional behaviors of participants.  Compared with control groups, children in the program showed better social skills, emotional recognition, and conversational skills.  The program is working on improving to a level where it can be distributed to communities.  Second, it's been shown in separate experiments that oxytocin may be able to improve facial expression and emotion recognition in autistic individuals.  The study was done on a small group of ADS-affected adolescents; the experimental group was given an oxytocin nasal spray and the control group a placebo spray.  The experimental group showed clear improvement in recognizing emotions and facial expressions, but they say more testing will be needed to back up these results before we can be sure.  Lastly, methods have been discovered involving DNA tagging, or methylation, to both diagnose autism disorders via blood tests or other DNA samples (rather than brain testing), and to potentially reverse its effects.  There wasn't much to the article, but I really look forward to hearing more!  :)



That's it for today, see you this weekend!
-Miss Mouse




References and Links:
Element 117
Multicellular Organisms Sans Oxygen
Volcanic Venus
Barometer of Life
Autism