Showing posts with label Pharmacology. Show all posts
Showing posts with label Pharmacology. Show all posts

Sunday, April 11, 2010

11 April 2010 - Stressed Mice, Tuned In Medicine, Drug Resistance, and Viruses Creating Energy

Hi!  Hope everyone had a great weekend.  :)

I don't know if you noticed or not, but I added this nifty little Twitter feature to the right hand side of the page, just under "Labels."  This is for those of you who don't want to wait for each post to see new headlines!  I'll be tweeting links to various articles I find here and there, or retweeting as the case may be.  Just a nifty little idea.

First off, experiments in mice have found that the brains of those mice with only one copy of a gene that produces "brain-derived neurotrophic factor," or BDNF, are more affected by stress.  Apparently, stress in these mice causes the hippocampus area of the brain to shrink and the dendrites to withdraw, whereas mice with the normal two copies of the gene, and therefore a normal amount of BDNF, show no physical change in that area of the brain.  Researchers are now searching to find ways to control the amount of BDNF protein so they can determine when in development supplementation would be most effective.  Very interesting!

I know I heard about hallucinogenic testing going on here and there in the recent past, but I just found another article about it.  Scientists are gathering in California this week for a pretty big conference on the topic, particularly for use with OCD, end of life anxiety, depression, PTSD, and other psychological disorders.  I cannot say this doesn't make me pretty happy.  Check out the article link at the bottom of the post to read about various tests and reactions to psilocybin in groovy experiments.  :)

Everyone's biggest fear when it comes to antibiotics is that a superbug will become resistant to everything and we'll have nothing left to beat infections with, right?  Or is that just mine?  In any case, researchers have taken a close look at vancomycin, the "last resort" antibiotic, and actually determined the mechanism by which bacteria develop resistance to it.  It had been debated whether bacteria were tipped off to the antibiotic by noticing it directly, or noticing what it was doing to their cell walls.  It turns out the former is the case, the knowledge of which may help to develop sneakier antibiotics that could still go unnoticed.  Considering the growing number of people who are affected by resistant infections, this is pretty great progress!

Last for the weekend - researchers have devised a more direct method of splitting water molecules for use in solar powered energy...things.  Mimicking the photosynthesis process of plants, a group of scientists have utilized a harmless virus in a gel (to hold conformation) to do the splitting so that hydrogen can be stored for use at any time, rather than only when the sun is shining.  Original in its particular method, the system is still in its creation phase and needs to become more cost effective, efficient, and complete before going into effect.  An end date isn't set, but it's a valuable concept and it's nice to see that it works!



Check out the Twitter feed on the right hand side of the page to see the articles I didn't include today, but were still pretty neat.

Thanks for reading, and I'll see you Tuesday!
-Miss mouse



References and Links:
Stressed Out Mice
Psychedelic Medicine
Resistance!
Virus Energy

Wednesday, April 7, 2010

6 April 2010 - Links

Hey!

I'm sorry, I was way too overwhelmed today to write a decent post, :( BUT I did find a bunch of great articles yesterday and today!  So, here are your links:

Armored T-Shirts

Nanotube black holes

Rising River Temperatures in the US

Early Emphysema Tests

Pyrimidines for Cancer Treatments

For Those Concerned about the Speed of Nano Progress without Health Testing (me)

Toxoplasmosis via the Iberian Lynx

Neurons Cooperating to Get Message Heard

Drug That Caused Birth Defects in 60s May Be Useful in Stopping Bleeding



Enjoy, and I'm sorry I couldn't write more!  I promise a real post on Thursday!  :)
-Miss Mouse

Thursday, April 1, 2010

1 April 2010 - Invisible Mice, Vegetable Lambs, Gene Therapy with Nano, and Lukewarm Planet Earth

First for today...check it out!  New news on the science world's favorite test animal.



















That's your prank for the day.  :)  Now, while I'm pretty nervous about browsing the headlines for serious happenings in science, here are a few that caught my eye anyway.

First, and only slightly less silly, a group of scientists are doing a broad study checking out several plants used in old medicines in Vietnam.  This has led them to the "vegetable lamb" plant, whose picture is simply too amazing not to include (credit "Wikimedia Commons"):


While this plant does NOT actually spawn baby sheep, like once thought, it does in fact contain interesting chemicals which prevent the body from breaking down bone.  Hopefully, this new information will lead to more doors opening for the many people affected by osteoporosis!





Next!  If you're familiar with gene therapy, you already know that to introduce new genes to a subject you need a vector, or something to carry those genes to where they need to go.  A virus makes a pretty good vector, but the world of nano seems to be offering better.  Scientists at Buffalo, Cleveland, and OKC have used a nanoparticle vector carrying a normal gene to replace faulty genes in mice with retinitis pigmentosa, a genetic disease that causes retinal cells to die and eventually cause blindness.  Mice injected with the carrier and gene both stopped deterioration of the retina cells AND experienced improved tissue, while mice injected with the gene alone or saline solution continued to lose vision.  In addition, there seemed to be no negative effects caused by the nanoparticle vector!

Lastly, researchers are taking global warming debates back a few billion years to attempt to explain why, if the sun was 30% dimmer 4 bya, was the planet not a completely frozen popsicle.  New findings in rock from Greenland shows CO2 content in the atmosphere of not more than 1000 ppm, which is around 3 times the current amount.  This shoots a bit of a hole in the idea that the planet stayed warm because of massive amounts of CO2 causing a greenhouse effect, but leaves a big question mark on why.  Those researchers are suggesting that perhaps reduced cloud cover (due to little of the required gases being produced by young life) in addition to greater ocean cover absorbing more sunlight could be the answer, but others argue these things could not have made enough of a difference, and that greenhouse gases still have to play a role to keep the earth thawed.  We'll see!



Thank you for reading, and I'll see you Sunday!
-Miss Mouse



References and Links:
Vegetable Lamb
Gene Therapy Helps Blind See
Lukewarm Earth 4 BYA